During menopause, estrogen levels decline, which can affect cartilage structure and metabolism. Scientific research shows that estrogen deficiency is associated with changes in joint tissues and reduced joint comfort, which is more common in women at this life stage (Yoon et al., 2018). Curcumin from Curcuma longa has been extensively studied and is traditionally used to support joint flexibility and mobility, especially with consistent use.

During menopause, hormonal fluctuations cause changes in muscle and joint function, which can contribute to stiffness and reduced movement comfort. Research in midlife women shows that declining estrogen is associated with changes in physical function and mobility (Messier et al., 2011). Targeted support that considers this life stage can help keep daily movement comfortable and maintain physical activity as part of a healthy lifestyle.

Broccoli extract contains bioactive compounds such as DIM (diindolylmethane) and sulforaphane. These compounds are studied for their role in estrogen metabolism and their influence on how estrogens are processed in the body. Scientific literature describes how DIM may be involved in modulating estrogen pathways, which explains why these compounds are often used in formulas for women during hormonal transitions such as menopause (Zeligs, 1998).

Curcumin, the active compound in Curcuma longa, has been extensively studied in relation to joint comfort and mobility. Clinical studies show that curcumin can help support physical function and comfort with consistent use, especially in adults with increased joint sensitivity (Daily et al., 2016). For this reason, curcumin is often used as a botanical support for maintaining long-term joint flexibility.

During menopause, hormonal changes and physical demands often occur together. Formulas that support both the musculoskeletal system and hormonal metabolism better meet the needs of this life stage. By combining botanical ingredients for joint comfort with compounds studied for their role in estrogen metabolism, this formula was developed to support the body during the hormonal transition characteristic of menopause (Yoon et al., 2018; Zeligs, 1998).

Curcumin naturally has low bioavailability. The addition of piperine, an active compound from black pepper (Piper nigrum), significantly increases curcumin absorption. Clinical research shows that piperine can enhance curcumin’s bioavailability by up to 2000%, allowing the active compounds to be used more efficiently by the body with daily intake (Shoba et al., 1998).