The Science Behind Insentials
At Insentials, we strongly believe in the power of science to promote health and well-being. Our supplements are not only based on thorough scientific research, but are also produced according to the highest standards for bioavailability and maximum absorption.
Every Insentials product is notified to the FPS Public Health. This is mandatory in Belgium before a supplement can be brought to market. Health claims are approved by EFSA after scientific evaluation. The EU applies one of the strictest regulatory frameworks in the world, with maximum limits for vitamins and minerals and strict labelling requirements.
Why are vitamins so important?
Vitamins are antioxidants that help neutralise free radicals and toxins. In addition to a healthy diet rich in vegetables, additional vitamins can help address deficiencies. External factors such as pollution, processed food, stress, etc. are often the cause of vitamin deficiencies. Antioxidants help support natural autophagy
Not all vitamins are equal. The quality of a vitamin can depend on a number of factors, including the source of the vitamin, the active form, and the derivation (natural vs. synthetic). The form (organic vs. inorganic) can also influence absorption, as can the synergy of taking multiple vitamins together.
At Insentials, we address all aspects of quality, maximum absorption, bioavailability and regulation.
Food today is far less nutritious
01
Carrots today contain a third less vitamin C than 50 years ago¹
A direct consequence of modern farming practices and soil depletion.
02
A vitamin D deficiency is linked to hormonal imbalance, including disruptions in oestrogen, insulin and cortisol²
Studies show that vitamin D receptors are present in virtually every hormone-producing tissue.
03
An overloaded liver can activate and metabolise vitamins less efficiently³
The liver plays a central role in activating vitamin D (conversion to 25-hydroxyvitamin D) and processing fat-soluble vitamins A, E and K. Under increased metabolic load, this capacity decreases.
Too Much of a Good Thing: The Risk of Vitamin Overdose!
Overdosing on vitamins can be harmful to your health. Although vitamins are essential for good health, taking too much of certain vitamins can be toxic and cause adverse effects.
Discover the power of vitamin synergy with Insentials. Our dedicated research reveals the remarkable health benefits of combining Insentials vitamins, without the risk of overdose.
The smart technology.
Smart Vitamins' unique slow release duocapsule technology is designed to release or release the vitamins more slowly for better absorption. This technology involves encapsulating the vitamins in a special coating so that the vitamins float in Omega3 rather than in fillers.
Smart Technology, Smart Vitamins. This is Insentials.
Treat the Cause, Not Just the Symptom
Vitamins are vital nutrients that support the proper functioning of our body.
Every vitamin has a unique role in the body, and deficiencies can lead to a variety of health and beauty issues such as weight gain, early menopause, skin ageing, acne, PCOS, fertility problems... Modern medicine addresses these symptoms with reactive remedies. We prefer to work alongside medicine to focus more on prevention.
The liver, first to become insulin resistant, plays a vital role in your body
Detox your liver. Revitalise your life!
The liver is a jack-of-all-trades in our body. We know it primarily as the detoxifier, the organ responsible for detoxifying or neutralising free radicals and toxins.
In this detoxification process, several chemical phases are naturally at work. The most important is glutathione, an endogenous antioxidant that we can produce ourselves, but not in sufficient quantities given our higher consumption.
The more toxic substances present internally (e.g. alcohol, sugar...) or externally (e.g. pollution, stress...), the greater our need.
The danger is that you don't feel an overloaded liver. You only feel it when it's too late. Taking preventive action on minor ailments such as waking up at night, difficulty losing weight, lack of energy, skin impurities, and hormonal imbalance means revitalising your life in the long term.
1 in 3 adults
heeft leververvetting (MASLD)⁵
First organ
dat insulineresistent wordt⁴
70%
of people with obesity or diabetes have fatty liver disease⁶
×5
higher diabetes risk with fatty liver disease⁷
Up to 80%
of fasting glucose regulated by the liver⁸
500+
functions performed by the liver every day
Fatty liver disease is often reversible in early stages. A weight loss of 5–10% can reduce liver fat by up to 30%⁹
| Result | What it is | What a reduction means | |
|---|---|---|---|
| ALT | −26,2% | Liver enzyme: rises under liver cell stress | Less pressure on the liver cells |
| AST | −20,7% | Liver enzyme: standard liver function test | Improved liver cell health |
| Triglycerides | −16,8% | Fats in the blood (indicator of metabolic load) | Less fat burden, better insulin sensitivity |
| Acetaldehyde | −18,6% | Breakdown product of alcohol in the liver | More efficient overnight alcohol processing |
| 12 weeks study | 80 participants |
Double-blind, placebo-controlled study — 12 weeks — 80 participants Source: Yen et al., Frontiers in Pharmacology, 2022.
Love your liver, lose the weight.
The liver plays a central role in fat metabolism and weight regulation and that goes beyond detox alone. The liver is the first organ to become insulin resistant⁴.
When the liver becomes chronically overloaded by excess calories, fructose, alcohol or metabolic stress, its capacity to burn fats efficiently decreases. Instead, the liver stores fats, a process that can lead to fatty liver disease (MASLD) and make weight control increasingly difficult⁵.
Visceral fat and liver fat reinforce each other: more liver fat leads to more insulin resistance, and more insulin resistance leads to more fat storage.
A Healthy Blood Sugar Level with Our Patented GLH-2 Formula
GLH-2 helps manage blood sugar and insulin levels and is beneficial for our metabolic health.
- Reduces the breakdown of sucrose and carbohydrates by up to 40%.
- This reduction leads to less uptake of glucose and fructose into the bloodstream, resulting in lower insulin secretion, reduced fat storage and increased fat use for energy.
- Improves insulin response and stimulates GLP-1 as undigested carbohydrates reach the ileum, signalling satiety and reducing cravings.
- Acts as a prebiotic for the microbiome and contributes to weight loss and the management of blood lipids.
Stabilise Every Day
Objective data (372 analyses, 2 weeks in real-life conditions):
- >99% of participants showed a measurable decrease in daily glucose variability.
- 75% less time in hyper- or hypoglycaemic zones.
- Effects visible from the first intake.
Our best-kept science secret?
The liver is a vital organ in the human body: it is the largest internal organ and performs more than 500 different functions. Your liver is the ultimate multitasker, but like every superhero, it has its limits.
Your liver is not only a filter; it is also a hormone-processing powerhouse. Hormones such as insulin, cortisol, and estrogen are all processed by the liver. When the liver does not function optimally, it can contribute to hormonal imbalances.
Radiant skin is a reflection of a healthy liver. Science confirms it: everything starts from within.
Smart Collagen Shot 10g
Any questions?
We'd be happy to assist you.
Yes. In Belgium, notification with the FPS Public Health is mandatory before a supplement can be placed on the market. Health claims must also be approved by EFSA following scientific assessment. Only then may they be used.
The debate is more about enforcement: whether every player actually complies with those rules. That is a legitimate discussion. But the framework exists, and we operate fully within it.
Our products fall under European legislation, one of the strictest frameworks in the world. That means: notification requirements, EFSA assessment of claims, maximum limits for vitamins and minerals, and strict labelling obligations.
Risks do exist in the market, but with illegally imported products that lack European approval. All Insentials products are notified with FASFC and comply with Belgian and European legislation.
Food remains the foundation. That is not up for debate. But eating healthily does not guarantee that you get everything your body needs. Sciensano documents structural deficiencies in the Belgian population for vitamin D, folic acid, iodine and omega-3.
For specific groups like pregnant women, older adults, vegetarians targeted supplementation is scientifically recommended, not optional. And even with a balanced diet, factors such as limited sun exposure, chronic stress and gut absorption capacity all play a role. Supplementation is not a replacement for food. It is targeted support where needed.
Partly a fair point. When supplements are promoted as a replacement for a healthy lifestyle, or when claims go beyond what the science supports, that criticism is justified.
But science clearly supports the added value of specific supplements in specific contexts: folic acid during pregnancy, vitamin D in winter, iron when deficient. The relevant question is not supplements: yes or no, but when, for whom and at what dose. That is precisely the starting point of Insentials.
That depends on what you mean by "compare". A supplement and a medicine both act on physiological processes but they do so in fundamentally different ways, with different goals and a different legal framework.
A good example is GLP-1 medication such as semaglutide (Ozempic). These are clinically registered medicines, developed for the treatment of type 2 diabetes and obesity, with strong pharmacological effects on satiety and weight. They fall under strict pharmaceutical legislation and require medical supervision.
Certain ingredients in food supplements such as DNJ from mulberry leaf can also influence related mechanisms, such as glucose absorption after a meal. This is scientifically supported and legitimate to communicate.
But a supplement does not replace medication. It is not a treatment for a disease. The mechanisms of action sometimes overlap; the clinical context and effect size do not. Supplements are support. Not therapy.
References
[1] Davis DR, Epp MD, Riordan HD. Changes in USDA food composition data for 43 garden crops, 1950 to 1999. J Am Coll Nutr. 2004;23(6):669–682. PubMed
[2] Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. Eur J Endocrinol. 2012;166(5):765–778. PubMed
[3] Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319–329. PMC
[4] Samuel VT, Shulman GI. Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases. Cell Metab. 2018. PubMed
[5] Surma S, Bułdak Ł. Metabolic dysfunction-associated steatotic liver disease (MASLD). Front Endocrinol. 2025. PMC
[6] Younossi ZM, et al. Global epidemiology of NAFLD/NASH. J Hepatol. 2023. PubMed
[7] Targher G, et al. Non-alcoholic fatty liver disease and risk of incident cardiovascular disease. Lancet. 2016. PubMed
[8] Roden M, Shulman GI. The integrative biology of type 2 diabetes. Nature. 2019;576:51–60. PubMed
[9] Vilar-Gomez E, et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015. PubMed
[10] Tsai SL, et al. Clinical Benefits of Golden-Antrodia camphorata Containing Antroquinonol in Liver Protection and Liver Fat Reduction After Alcoholic Hepatitis. Front Pharmacol. 2022;13:757494. PMC
[11] Thondre PS, et al. Understanding the Impact of Different Doses of Reducose® Mulberry Leaf Extract on Blood Glucose and Insulin Responses after Eating a Complex Meal. Nutrients. 2024;16(11):1670. DOI
[12] Proksch E, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology. Skin Pharmacol Physiol. 2014;27(1):47–55. PubMed
[13] Kim DU, et al. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin. Nutrients. 2018;10(7):826. PMC
[14] Pu SY, et al. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis. Nutrients. 2023. PubMed