The Science Behind Insentials
At Insentials, we firmly believe in the power of science to promote health and well-being. Our supplements are not only based on thorough scientific research, but are also produced according to the highest standards for bioavailability and maximum absorption.
Each Insentials product is notified to the FPS Public Health. This is mandatory in Belgium before a supplement can be placed on the market. Health claims are approved by EFSA after scientific assessment. The EU applies one of the strictest regulatory frameworks in the world, with maximum limits for vitamins and minerals and strict labelling obligations.
Why are vitamins so important?
Vitamins are antioxidants that help neutralize free radicals or toxins. In addition to a healthy diet rich in vegetables, additional vitamins can help address deficiencies. External factors, such as pollution, processed foods, stress, etc., are often the cause of vitamin deficiencies. Antioxidants help support natural autophagy.
Not all vitamins are created equal. The quality of a vitamin can depend on a number of factors, including the source of the vitamin, the active form, the derivation (natural versus synthetic). The form (organic versus inorganic) can also affect absorption, as can the synergy of taking multiple vitamins.
At Insentials, we address all aspects of quality, maximum absorption, bioavailability & regulations.
Food is much less nutritious today
01
Carrots today contain one-third less vitamin C than 50 years ago¹
A direct consequence of modern agricultural practices and soil depletion.
02
A vitamin D deficiency is linked to hormonal imbalances including disruptions in estrogen, insulin, and cortisol²
Studies show that vitamin D receptors are present in almost every hormone-producing tissue.
03
An overburdened liver can activate and metabolize vitamins less efficiently³
The liver plays a central role in the activation of vitamin D (conversion to 25-hydroxyvitamin D) and the processing of fat-soluble vitamins A, E, and K. Under increased metabolic stress, this capacity decreases.
Too much of a good thing: the risk of a vitamin overdose!
Overdosing on vitamins can be harmful to your health. While vitamins are essential for good health, taking too much of certain vitamins can be toxic and cause adverse effects.
Discover the power of vitamin synergy with Insentials. Our dedicated research reveals the remarkable health benefits of combining Insentials vitamins, without the risk of overdose.
The smart technology.
The unique slow-release duo-capsule technology of Smart Vitamins is designed to release vitamins more slowly for better absorption. This technology means that the vitamins are encapsulated in a special coating, so that the vitamins float in Omega-3 instead of in fillers.
Smart technology, Smart Vitamins. This is Insentials.
Tackling the cause, not just the symptom.
Vitamins are vital nutrients that support the proper functioning of our bodies.
Each vitamin has a unique role in the body, and deficiencies can lead to a variety of health and beauty ailments such as weight gain, premature menopause, skin aging, acne, PCOS, fertility problems, etc. Current medicine addresses these symptoms with reactive remedies. We would like to work with medicine on more prevention.
The liver, being the first organ to become insulin resistant, plays a vital role in your body⁴
Detox your liver. Revitalize your life!
The liver is a jack-of-all-trades in our body. We mainly know it as the detoxifier; the organ that ensures our detoxification or neutralization of free radicals and toxins.
In this detoxification process, various chemical phases are naturally at work. The most important is glutathione, an endogenous antioxidant that we can produce ourselves, but not sufficiently given our higher consumption.
The more toxic substances there are internally (e.g., alcohol, sugar, ...) or externally (e.g., pollution, stress, ...), the greater our need.
The danger is that you don't feel a burdened liver. You only feel it when it's too late. Proactively addressing your minor ailments such as waking up at night, difficulty losing weight, energy deficiencies, skin impurities, and hormonal imbalance is revitalizing your life in the long term.
Discover the science behind glutathione
1 in 3 adults
has fatty liver disease (MASLD)⁵
First body
that becomes insulin-resistant⁴
70%
overweight/diabetes leads to fatty liver⁶
×5
higher diabetes risk with fatty liver⁷
Up to 80%
from fasting glucose regulated by the liver⁸
500+
functions performed by the liver per day
Fatty liver disease is often reversible in its early stages. A weight loss of 5–10% can reduce liver fat by up to 30%⁹
| Result | What it is | What a decline means | |
|---|---|---|---|
| ALT | -26.2% | Liver enzyme: increases with liver cell stress | Less pressure on the liver cells |
| AST | -20.7% | Liver enzyme: standard liver function test | Improved liver cell health |
| Triglycerides | -16.8% | Fats in the blood (indicator of metabolic stress) | Reduced fat taxation, improved insulin sensitivity |
| Acetaldehyde | -18.6% | Alcohol breakdown product in the liver | More efficient alcohol processing at night |
| Study 12 weeks | n = 80 participants |
Double-blind, placebo-controlled study — 12 weeks — 80 participantsSource: Yen et al., Frontiers in Pharmacology, 2022.
Love your liver, lose the weight.
The liver plays a central role in fat metabolism and weight regulation, and this goes beyond detoxification alone. The liver is the first organ to become insulin resistant⁴.
When the liver becomes chronically overloaded due to an excess of calories, fructose, alcohol, or metabolic stress, its capacity to efficiently burn fats decreases. Instead, the liver stores fats, a process that can lead to fatty liver disease (MASLD) and make weight control increasingly difficult⁵.
Visceral fat and liver fat reinforce each other: more liver fat leads to more insulin resistance, and more insulin resistance leads to more fat storage.
Healthy blood sugar levels with our patented GLH-2 formula
GLH-2 helps control blood sugar and insulin levels and is beneficial for our metabolic health.
- Reduces the breakdown of sucrose and carbohydrates by up to 40%.
- This reduction leads to less absorption of glucose and fructose into the bloodstream, resulting in lower insulin secretion, reduced fat storage, and increased fat utilisation for energy.
- Improves insulin response and stimulates GLP-1 by allowing undigested carbohydrates to reach the ileum, signalling satiety and reducing cravings.
- Acts as a prebiotic for the microbiome and contributes to weight loss and the control of blood lipids.
Stabilize Every Day
Objective data (372 analyses, 2 weeks of real-life conditions)
>99% of participants showed a measurable decrease in daily glucose variability.
75% less time in hyper- or hypoglycemic zones.- Effects visible from the first intake.
Our best-kept scientific secret?
The liver is an important organ in the human body: it's the largest internal organ and performs over 500 different functions. Your liver is the ultimate multi-tasker, but like any superhero, it has its limits.
Your liver is not just a filter; it's also a hormone factory. Hormones like insulin, cortisol, and estrogen are all processed by the liver. If the liver isn't functioning optimally, this can lead to an imbalance in these hormones.
Radiant skin is a reflection of a healthy liver. Science confirms: everything starts from within.
Smart Collagen Shot 10g
Questions?
We are happy to help you.
Yes. In Belgium, notification to the FPS Public Health is mandatory before a supplement can be placed on the market. Health claims must also be approved by EFSA after scientific evaluation. Only then may they be used.
The debate is more about enforcement: whether every player actually complies with those rules. That is a legitimate discussion. But the framework exists, and we operate fully within it.
Our products fall under European regulations, one of the strictest frameworks in the world. This means: notification requirements, EFSA assessment of claims, maximum limits for vitamins and minerals, and strict labelling obligations.
Risks do exist in the market, but with illegally imported products without European approval. All Insentials products are FASFC-notified and comply with Belgian and European legislation.
Nutrition remains the foundation. That is not debatable. However, healthy eating does not guarantee that you get everything your body needs. Sciensano documents structural deficiencies in the Belgian population for vitamin D, folic acid, iodine, and omega-3.
For specific groups such as pregnant women, the elderly, and vegetarians, targeted supplementation is scientifically recommended. Even with a balanced diet, factors such as limited sun exposure, chronic stress, and the absorption capacity of the gut play a role. Supplementation is not a substitute for nutrition. It is targeted support where necessary.
When supplements are promoted as a replacement for a healthy lifestyle, or when claims go beyond what science permits, that criticism is justified.
However, science clearly supports the added value of specific supplements in specific contexts: folic acid during pregnancy, vitamin D in winter, iron for a deficiency. The relevant question is not supplements: yes or no, but when, for whom, and in what dose. That is precisely the starting point for Insentials.
That depends on what you mean by "compare". A supplement and a medicine both act on physiological processes, but they do so in a fundamentally different way, with different objectives and a different legal framework.
A good example is GLP-1 medication like semaglutide (Ozempic). These are clinically registered medicines, developed for the treatment of type 2 diabetes and obesity, with strong pharmacological effects on satiety and weight. They fall under strict drug legislation and require medical follow-up.
Certain ingredients in food supplements, such as DNJ from mulberry leaf, can also affect related mechanisms, such as glucose absorption after a meal. This is scientifically substantiated and legitimate to communicate.
But a supplement does not replace a medicine. It is not a treatment for a disease. The mechanisms of action sometimes overlap; the clinical context and effect size do not. Supplements are supportive. Not therapy.
References
[1] Davis DR, Epp MD, Riordan HD. Changes in USDA food composition data for 43 garden crops, 1950 to 1999. J Am Coll Nutr. 2004;23(6):669–682. PubMed
[2] Lerchbaum E, Obermayer-Pietsch B. Vitamin D and fertility: a systematic review. Eur J Endocrinol. 2012;166(5):765–778. PubMed
[3] Bikle DD. Vitamin D metabolism, mechanism of action, and clinical applications. Chem Biol. 2014;21(3):319–329. PMC
[4] Samuel VT, Shulman GI. Nonalcoholic fatty liver disease as a nexus of metabolic and hepatic diseases. Cell Metab. 2018. PubMed
[5] Surma S, Bułdak Ł. Metabolic dysfunction-associated steatotic liver disease (MASLD). Front Endocrinol. 2025. PMC
[6] Younossi ZM, et al. Global epidemiology of NAFLD/NASH. J Hepatol. 2023. PubMed
[7] Targher G, et al. Non-alcoholic fatty liver disease and risk of incident cardiovascular disease. Lancet. 2016. PubMed
[8] Roden M, Shulman GI. The integrative biology of type 2 diabetes. Nature. 2019;576:51–60. PubMed
[9] Vilar-Gomez E, et al. Weight loss through lifestyle modification significantly reduces features of nonalcoholic steatohepatitis. Gastroenterology. 2015. PubMed
[10] Tsai SL, et al. Clinical Benefits of Golden-Antrodia camphorata Containing Antroquinonol in Liver Protection and Liver Fat Reduction After Alcoholic Hepatitis. Front Pharmacol. 2022;13:757494. PMC
[11] Thondre PS, et al. Understanding the Impact of Different Doses of Reducose® Mulberry Leaf Extract on Blood Glucose and Insulin Responses after Eating a Complex Meal. Nutrients. 2024;16(11):1670. DOI
[12] Proksch E, et al. Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology. Skin Pharmacol Physiol. 2014;27(1):47–55. PubMed
[13] Kim DU, et al. Oral Intake of Low-Molecular-Weight Collagen Peptide Improves Hydration, Elasticity, and Wrinkling in Human Skin. Nutrients. 2018;10(7):826. PMC
[14] Pu SY, et al. Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis. Nutrients. 2023. PubMed